A model for shear stress-induced deformation of a flow sensor on the surface of vascular endothelial cells.
Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates. Atelectrauma disrupts pulmonary epithelial barrier integrity and alters the distribution of tight junction proteins ZO-1 and claudin 4. The identification of ECs mechanosensors involved in early stages of EC-cancer cell interaction will help with developing more efficient therapeutic interventions to suppress cancer cell transmigration in the microvasculature.Īnne-Marie, J., and P. This finding reveals the role of organ-specific stiffness in promoting cancer cell transmigration even in capillaries larger than cancer cell diameter.Ĭonclusions-ÊCancer cell-induced-changes in ECs mechanotransduction represents an important potential mechanism for cancer cell transmigration in the microvasculature particularly with stiffer ECM.
Impact of ECM stiffness is particularly significant in ECs exposed to fluid shear stresses of 2 Pa or lower. Furthermore, we demonstrate that ADJs, FAs, and SFs experience higher stresses in ECs attached to stiffer ECM. This impact is more drastic on stress fibers (SFs) both centrally located and peripheral ones. Results-Our results show that cancer cell-altered hemodynamics results in significantly high forces transmitted to subcellular organelles of ECs which are in vicinity of cancer cells. Methods-A three-dimensional, multiscale, multicomponent, viscoelastic model of focally adhered ECs is developed to simulate the force transmission through ECs mechanosensors. The second objective of this study is to elucidate the role of ECM stiffness on mechanotransduction in ECs. However, it is still not well understood how ECM stiffness impacts ECs mechanosensors. Moreover, extracellular matrix (ECM) stiffening has been shown to correlate with progression of most cancer types. The first objective of present study is to explore how cancer cell-induced changes in local hemodynamics can impact the forces experienced by intra/inter-cellular organelles of ECs that are believed to play important roles in mechanotransduction. On the other hand, cancer cells are shown to influence the local hemodynamics in their vicinity, in microvasculature. Send us feedback.Introduction-Local hemodynamics impact the mechanotransduction in endothelial cells (ECs) lining the vascular network. These example sentences are selected automatically from various online news sources to reflect current usage of the word 'vicinity.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. San Diego Union-Tribune, 7 July 2022 See More
Rachel Pannett, Washington Post, 27 July 2022 The emergency alarm went off Tuesday morning, warning many in the area that there was a problem at the plant and advising them to evacuate the vicinity.įrom Usa Today Network And Wire Reports, USA TODAY, 18 July 2022 The emergency alarm went off Tuesday morning, warning many in the area that there was a problem at the plant and advising them to evacuate the vicinity.įox News, 15 July 2022 After surveying the culinary scene, Foshee found there weren’t any restaurants in the vicinity that specialized in fresh oyster service. 2022 Other artifacts found in the weapon’s vicinity included metal anchors, stone anchors and pottery fragments. 2022 The emergency alarm went off Tuesday morning, warning many in the area that there was a problem at the plant and advising them to evacuate the vicinity.įrom Usa Today Network And Wire Reports, USA TODAY, 18 July 2022 Elaine Bain posted a video to Facebook, saying the black bear was spotted in West Peabody, in the vicinity of Corbeil Park and a nearby bike path.ī, 8 Aug. Sam Whiting, San Francisco Chronicle, 23 Aug. 2022 The incident was filmed by a resident of the vicinity of Lake Street and 14th Avenue in the Richmond District. Recent Examples on the Web The entire street and adjacent streets have felt the impulse given by the award of that contact, so that the vicinity of the theater has been entirely changed within the last eighteen months.
0 kommentar(er)
